Our brains contain 100 billion neurons that make 100 trillion connections. These neurons have both digital and analog properties. When active they release one or more of dozens of different neurotransmitters, which activate hundreds of different receptors. The complexity makes a computer circuit board look like an abacus compared to a super-computer. The challenge: we understand little of how the brain computer works and why it falters in age and disease. And yet super-simplified neural circuits in sufficient number already beat us at Chess, write term papers and legal briefs that we struggle to criticize and generate images that we have trouble distinguishing from authentic. Where does this put the effort to understand brain function, cure neurodegenerative and neuropsychiatric disease, and create a sustainable future?